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Wellbutrin XL Without Prescription

  • Generic name: Bupropion hcl
  • Brand names: Wellbutrin SR, Wellbutrin XL, Zyban
  • Therapeutic class: Antidepressant, Norepinephrine and Dopamine Reuptake Inhibitor

Wellbutrin is a prescription antidepressant with very distinct dopaminergic activity. It is used to relieve the symptoms of depression, and to prevent autumn-winter seasonal depression (seasonal affective disorder). Bupropion may be very useful for depression accompanied with hypersomnia and fatigue. Persons who experience apathy, poor attention, lack of motivation may do well with Wellbutrin.

Bupropion is less likely to erode sexual desire and opportunities. Moreover, it can increase libido and intensity of orgasm. Another significant advantage is that the long-term treatment doesn't contribute to extra pounds.

Generic Wellbutrin SR

Description Quantity Pharmacy Price Buy
Bupropion SR 150 mg 30 tablets 4RX $19
Bupropion SR 150 mg 60 tablets 4RX $36
Bupropion SR 150 mg 120 tablets 4RX $66
Bupropion SR 150 mg 240 tablets 4RX $119
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Consumer Information

Bupropion was first synthesized by Burroughs Research in 1966, and patented by Burroughs-Wellcome (later Glaxo-Wellcome) in 1974. It was approved by the FDA in 1985 and marketed under the name Wellbutrin.

There are three formulations of bupropion hcl. The main difference is how the medicine is released into the system and the time it takes for your body to digest and process it: immediate-release (needs to be taken 3 times daily), sustained-release (Wellbutrin SR, needs to be taken twice daily) and extended-release (Wellbutrin XL, once daily formulation).

In general the slower release forms are better for most people, so XL will be better than SR and SR is better than immediate release. But not always.

Wellbutrin is not a perfect option for anxious and agitated persons, who may be particularly vulnerable to its stimulating properties.

On the other hand, sluggish and obese persons as well as smokers and ADHD sufferers may benefit from the energizing and anticraving properties of bupropion.

How to take

  • Start bupropion at a low dosage and gradually increase it; this helps to minimize the side effects.
  • Swallow tablets whole without chewing, dividing, or crushing them.
  • Don't buy and take Wellbutrin XL or SR if you have a history of seizures, epilepsy, or eating disorder (e.g. bulimia or anorexia nervosa), or if you are taking monoamine oxidase (MAO) inhibitors.
  • Do not drink alcohol while you are taking Wellbutrin; an interaction with alcohol can increase the possibility of seizures.
  • Wellbutrin is contraindicated in patients undergoing abrupt discontinuation of alcohol or benzodiazepines.

Dosing

Wellbutrin XL

Wellbutrin XL (extended release) is sold in two prescription strengths, 150 mg and 300 mg, to allow for dosing flexibility.

The starting dose is 150 mg taken once a day in the morning. If this dose is well tolerated after a minimum of 3 days, it may be increased to 300 mg, also taken once a day in the morning. If no improvement is seen after several weeks of treatment, the dose may be increased to a maximum of 450 mg once a day.

Wellbutrin SR

For bupropion SR the starting dose is 100 mg twice a day, increase to 150 mg twice a day after at least 3 days. If there is no satisfactory results after 4 weeks the total daily dose may be increased up to 400 mg.

If you have severe liver damage, use Wellbutrin with extreme caution. You should not exceed 150 mg every other day. People with mild to moderate liver damage or kidney impairment will be prescribed a lower dose as well.

Quick facts
wellbutrin xl
bupropion hcl
  • Wellbutrin XL is a new prescription formulation of bupropion that offers convenient once-daily dosing and is less likely to induce seizures.
  • The XL form is safer and better tolerated, than SR form, but is more expensive, so the benefits may be negated by cost issues.
  • Soon after its release, Wellbutrin was temporarily removed from the market due to the occurrence of seizures in some patients. However, further investigation showed that seizures were primarily associated with high doses (above the current recommended maximum of 450 mg/day), a history of seizures or brain trauma, or excessive alcohol use.
  • False-positive for amphetamine.
    Bupropion, an active ingredient of Wellbutrin XL, has a structure similar to stimulants, and may cause urinary tests to read a positive result in both amphetamines and occasionally, methamphetamine categories.