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September 07, 2008


Buy Valtrex No Prescription


Brief Information
  • Active ingredient: Valacyclovir hydrochloride
  • Common brand names: Valtrex
  • Drug class: Antiviral, nucleoside analogue
  • Pregnancy category: B
  • Dosages: 500 mg, 1000 mg tablets
  • FDA approved: 12/15/1995
  • Company name: GlaxoSmithKline
  • Avalable as generic? No

Buying Information

Medication Quantity Pharmacy Price Shipping Buy
Valtrex 500 mg 30 tablets JRB Health Solutions LLC $218 $15
MPLLC.net $219 $18
Valtrex 500 mg 60 tablets JRB Health Solutions LLC $357 $15
Valtrex 500 mg 90 tablets MPLLC.net $449 $18
JRB Health Solutions LLC $540.34 $15
Valtrex 1000 mg 21 tablets MPLLC.net $329 $18
Valtrex 1000 mg 42 tablets MPLLC.net $549 $18
Valtrex 1000 mg 90 tablets MPLLC.net $799 $18

  • Health Solutions Network (MPLLC) payment methods: Visa, Money Order, E-check.
  • JRB Health Solutions LLC payment methods: Mastercard, Visa, Money Order.
  • Delivery: FedEx next day (Overnight) air delivery, Saturday delivery also available.
  • All orders are shipped from US.
  • No prescription required.
  • Free online doctor consultation.

Buy Valtrex online with no prescription
If you would like to buy Valtrex online, choose the offer from the above Valtrex price tables and click on the Buy link. You will be taken to the secure server of our suppliers, US based companies Health Solutions Network (subsidiary of Millenium Pharmaceuticals, LLC) or JRB Health Solutions LLC, to complete your Valtrex order.


Detailed Information

Valtrex (Valacyclovir hydrochloride) is an antiviral agent, active against most species in the herpes virus family. It slows the growth and spread of the herpes virus so that the body can fight off the infection and lessens the symptoms of these infections and shortens the length of time you are sick. The drug works best if it is used within 48 hours after the first symptoms of shingles or herpes begin to appear. Valtrex does not cure herpes virus infections.

Valtrex is indicated for:

  • treatment or suppression of genital herpes and for the suppression of recurrent genital herpes
  • reduction of transmission of genital herpes
  • treatment of herpes zoster (shingles)
  • treatment of cold sores (herpes labialis)

Off-label uses:

  • herpes simplex keratitis 1
  • recurrent genital herpes in pregnant women 4

Advantages:

  • convenient less frequent dosing regimen (potential for improved compliance)
  • high oral bioavailability 2
  • proven in clinical trials to reduce the risk of HSV sexual transmission
  • highly effective
  • safe and well-tolerated
  • more effective than acyclovir for herpes zoster 3

Disadvantages:

  • cannot eradicate latent virus
  • costs can be significantly higher than the cost of generic acyclovir

How Valtrex works
Valacyclovir is a chemical able to enter viral infected host cells. Once in the cell, it is activated by viral enzymes, then mimic a DNA nucleotide - a molecule needed for replication by the virus. Once the molecule binds to any viral DNA under production, it will terminate the production process. The result is that the virus cannot reproduce, thereby stopping it shedding and spreading to other cells.

How effective is Valtrex (valacyclovir) in preventing HSV transmission
This medication is highly effective. It reduces transmission of overall genital herpes infection (HSV-2 seroconversion) by 50% and of symptomatic genital herpes by 75%.

Valtrex (valacyclovir) vs. Famvir (famciclovir)
Valacyclovir appear to be somewhat better than famciclovir for suppression of genital herpes and associated shedding. Acyclovir and penciclovir appear to have different ability to abrogate HSV reactivation. (Comparative efficacy of famciclovir and valacyclovir for suppression of recurrent genital herpes and viral shedding)

Valacyclovir treatment is comparable to famciclovir treatment in speeding the resolution of zoster-associated pain and postherpetic neuralgia. Current prices indicate that valacyclovir is the more cost-effective treatment for herpes zoster than famciclovir. (Antiviral therapy for herpes zoster)

Valacyclovir vs. Acyclovir
Valacyclovir has several advantages over acyclovir: exhibits significantly greater oral bioavailability, results in higher blood levels, and can be given less frequently. It is at least as efficacious. However, valacyclovir is more expensive than off-patent acyclovir.

Twice-daily valacyclovir is as effective and well tolerated in the treatment of recurrent genital HSV infection as 5-times-daily acyclovir. Valacyclovir can prove a useful alternative to acyclovir when convenience of dosing or compliance issues are the prime considerations in treatment. (Comparison of oral valacyclovir and acyclovir in immunocompetent patients with recurrent genital herpes)

In the management of herpes zoster, valaciclovir accelerates the resolution of pain and offers a simpler dosing, and maintains the favorable safety profile of acyclovir. (Comparative study of the efficacy and safety of valaciclovir versus acyclovir in the treatment of herpes zoster)



References
  • 1. Sozen E, Avunduk AM, Akyol N. Comparison of efficacy of oral valacyclovir and topical acyclovir in the treatment of herpes simplex keratitis: a randomized clinical trial. Chemotherapy. 2006;52(1):29-31. PubMed
  • 2. Bras AP, Sitar DS, Aoki FY. Comparative bioavailability of acyclovir from oral valacyclovir and acyclovir in patients treated for recurrent genital herpes simplex virus infection. Can J Clin Pharmacol. 2001 Winter;8(4):207-11. PubMed
  • 3. Beutner KR, Friedman DJ, Forszpaniak C, Andersen PL, Wood MJ. Valaciclovir compared with acyclovir for improved therapy for herpes zoster in immunocompetent adults. Antimicrob Agents Chemother. 1995 Jul;39(7):1546-53. PubMed
  • 4. Andrews WW, Kimberlin DF, Whitley R, Cliver S, Ramsey PS, Deeter R. Valacyclovir therapy to reduce recurrent genital herpes in pregnant women. Am J Obstet Gynecol. 2006 Mar;194(3):774-81. PubMed
Interesting facts

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Valtrex facts
  • Valtrex is the first and only once-daily herpes antiviral medication clinically proven to reduce the number of herpes outbreaks.
  • Many people on daily therapy with Valtrex may go a year outbreak-free.
  • Valtrex is the only medication proven to reduce the risk of spreading genital herpes to a partner.
  • Valtrex 500 mg once daily can reduce the transmission of genital herpes to uninfected partner by 50-75%, when used in combination with safer sex practices.



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