Ultracet Prescription

• Generic name: Tramadol Acetaminophen
• Brand names: Ultracet, Tramacet
• Therapeutic class: Central Analgesic

Ultracet is a combination of opioid analgesic tramadol (37.5 mg) and non-opioid, non-salicylate analgesic acetaminophen (325 mg). It is approved for short term management of acute pain. Ultracet provides rapid onset combined with prolonged analgesia.

Benefits: Ultracet begins working faster than tramadol alone, and provides long-lasting pain relief. It is not an NSAID and may be a good choice for people with risk of stomach ulcers, kidney problems, or who are taking antihypertensive drugs.

Risks: The most common side effects are constipation, sleepiness, and increased sweating. Although Ultracet is very effective and relatively safe, some people should not take it, particularly without a prescription and doctor's approval:

• It is dangerous for people who have a history of severe, life-threatening allergic reactions to opioids (e.g. codeine).
• Ultracet is not a suitable prescription for those who have a tendency to abuse drugs or alcohol, or a history of opioid dependence.

Buy Ultracet (Tramadol Acetaminophen)

Ultracet, a prescription pain reliever originally developed by Ortho-McNeil, is widely available as generic. So if you are about to buy Ultracet, you may want to check price for lower-cost generic tramadol/acetaminophen.

Description	Quantity	Pharmacy	Price	Buy
Ultracet (Ortho-McNeil)	30 tablets	MPLLC	$112
Ultracet (Ortho-McNeil)	60 tablets	MPLLC	$162
Ultracet (Ortho-McNeil)	90 tablets	MPLLC	$212
Tramadol APAP 37.5/325 mg	30 tablets	MPLLC	$82
Tramadol APAP 37.5/325 mg	60 tablets	MPLLC	$98
Tramadol APAP 37.5/325 mg	90 tablets	MPLLC	$117

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Ultracet Comparison

Ultracet offers a worthy alternative to other acetaminophen plus a weak opioid combinations and NSAIDs. The following information would be helpful for our visitors in choosing the right medication.

Ultracet versus Hydrocodone/Acetaminophen

According to the clinical study, Ultracet provides effective rapid analgesia comparable to that of Hydrocodone/Acetaminophen with lower rate of side effects1. In the study the onset of pain relief was about 34 minutes with Ultracet and 25.4 minutes with Hydrocodone/Acetaminophen. The incidence of nausea and vomiting was about 50% lower with Tramadol/Acetaminophen combination.

Results of the ankle sprain study showed that Ultracet and Hydrocodone/Acetaminophen had comparable utility in relieving pain caused by ankle sprain4.

Ultracet versus Codeine/APAP

The results of another study suggest that Ultracet (37.5 mg/325 mg) is as effective as Codeine/APAP (30 mg/300 mg) in the treatment of chronic low back pain and osteoarthritis pain. Codeine/APAP causes higher rate of sleepiness and constipation whereas Ultracet causes more headache2.

Ultracet versus Gabapentin

Ultracet is as effective in relieving painful diabetic neuropathy as gabapentin, according to the Korean study. The overall improvements in pain intensity were –3.11 and –2.70 for the tramadol/acetaminophen and gabapentin groups respectively5.

Ultracet in migraine

Ultracet may be a suitable option for the management of moderate-to-severe migraine headache3. It reduces the severity of pain, photophobia, and phonophobia associated with migraine headache, but does not reduce migraine-associated nausea.

• 1. Fricke JR, Karim R, Jordan D, Rosenthal N. Comparison of the analgesic efficacy of tramadol/acetaminophen, hydrocodone/acetaminophen, and placebo after oral surgery. Clin Ther. 2002 Jun;24(6):953-68.
• 2. Mullican WS, Lacy JR; TRAMAP-ANAG-006 Study Group. Tramadol/acetaminophen combination and codeine/acetaminophen combination for the management of chronic pain: a comparative trial. Clin Ther. 2001 Sep;23(9):1429-45. PubMed
• 3. Silberstein SD, Freitag FG, Rozen TD, Kudrow DB, Hewitt DJ, Jordan DM, Fisher AC, Rosenthal NR; CAPSS-223 Investigators. Tramadol/acetaminophen for the treatment of acute migraine pain: findings of a randomized, placebo-controlled trial. Headache. 2005 Nov-Dec;45(10):1317-27. PubMed
• 4. Hewitt DJ, Todd KH, Xiang J, et al. Tramadol/acetaminophen or hydrocodone/acetaminophen for ankle sprain: a randomized, placebo-controlled trial. Ann Emerg Med. 2007 Apr;49(4):468-80, 480.e1-2.
• 5. Ko SH, Kwon HS, Yu JM, et al. Comparison of tramadol/acetaminophen combination therapy and gabapentin in the treatment of painful diabetic neuropathy. Diabet Med. 2010 Sep;27(9):1033-40. PubMed