Tramadol APAP Prescription

Tramadol with APAP is a powerful pain medicine that combines 37.5 mg tramadol hydrochloride and 325 mg acetaminophen. It is used to treat medium to severe pain. It is inexpensive and available as generic in the U.S.

The combination of two analgesics provides enhanced efficacy, faster onset of pain relief and longer duration of analgesia than either component alone. Tramadol APAP begins to work within 17 minutes and lasts for more than 5 hours1.

This prescription is effective for many kinds of pain, including muscle aches, back and neck pain, fibromyalgia, joint pain, post-operative aches, and migraine headaches. When Tramadol APAP is used for the short-term (5 days or less) it provides all benefits without any serious side effects and dependence problems.

Tramadol Acetaminophen

Description	Quantity	Pharmacy	Price	Buy
Tramadol APAP 37.5/325 mg	30 tablets	MPLLC	$82
Tramadol APAP 37.5/325 mg	60 tablets	MPLLC	$98
Tramadol APAP 37.5/325 mg	90 tablets	MPLLC	$117

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How does Tramadol/APAP work?

Tramadol is a unique non-scheduled opioid. Its analgesic action involves a complementary dual mechanism: mild µ-opioid receptor binding and inhibition of norepinephrine and serotonin reuptake.

Acetaminophen, also known as paracetamol, is sold over-the-counter under the brand Tylenol. It appears to work by increasing the pain threshold via inhibition of prostaglandin synthesis and indirect activation of cannabinoid CB(1) receptors.

The combination of analgesics with different mechanisms of action, albeit at reduced doses, provides superior pain relief with no increase in side effects.

The safety profile of this combination, especially the low incidence of tolerance, dependence, constipation and somnolence, makes it an attractive substitute for traditional opioid analgesics.

Dosage

• Do not take Tramadol/Acetaminophen 37.5-325 more than prescribed. An overdose can be fatal. The maximum quantity is 2 tablets per dose, or 8 tablets per day.
• Avoid Tramadol APAP if you have had an allergic reaction to either of its ingredients, or to any other narcotic pain reliever. It may cause serious and in some cases fatal allergic reactions, typically after the first dose.
• Tramadol may interact with alcohol, other CSN depressants, and warfarin. You should not take it if you are intoxicated.
• Acetaminophen and tramadol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
• It is contraindicated in any situation where opioids are contraindicated.

The usual Tramadol APAP prescription for pain relief for adults and adolescents 16 years and older is 2 tablets every 4-6 hours as needed for up to 5 days. Don't take more than two tablets at a time or more than 8 tablets within 24 hours.

If your kidney function is below normal or you are over 75 years old, the maximum dose is 2 tablets three times per day.

Tramadol is a powerful analgesic with potential for abuse, and is not sold without a prescription.

Tramadol is not a scheduled substance in the Controlled Substances Act. However, in some states it is a schedule IV substance.

• 1. Medve RA, Wang J, Karim R. Tramadol and acetaminophen for dental pain. Anesth Prog 2001;48: 79-81. PubMed