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July 24, 2008



Prescription Muscle Relaxers

Skeletal muscle relaxants are a heterogeneous group of medications. As a class, they are structurally and pharmacologically diverse. Muscle relaxants are used to treat two different types of underlying conditions:

  • spasticity from upper motor neuron syndromes
  • muscular pain or spasms from peripheral musculoskeletal conditions

Although muscle relaxants have by convention been classified into one group, the Food and Drug Administration (FDA) has approved only a few medications in this class for treatment of spasticity. The remainder are approved for treatment of musculoskeletal conditions.

Drugs classified as skeletal muscle relaxants include:

Only baclofen, dantrolene, and tizanidine are approved for treatment of spasticity. Carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine have been approved for treatment of musculoskeletal disorders, but not for spasticity. There is no conclusive evidence to suggest that any one skeletal muscle relaxant is superior to another.

Spasticity

Spasticity is a state of increased muscular tone with exaggeration of the tendon reflexes. Conditions associated with spasticity and requiring treatment include multiple sclerosis, spinal cord injury, traumatic brain injury, cerebral palsy, and poststroke syndrome. In many patients with these conditions, spasticity can be disabling and painful with a marked effect on functional ability and quality of life.

Musculoskeletal conditions

Muscle spasm is defined as a sudden involuntary contraction of one or more muscle groups and is usually an acute condition associated with muscle strain (partial tear of a muscle) or sprain (partial or complete rupture of a ligament). Common musculoskeletal conditions causing tenderness and muscle spasms include fibromyalgia, tension headaches, myofascial pain syndrome, and mechanical low back pain or neck pain.

Some physicians refer to muscle spasm as part of the spasm-pain-spasm cycle. The muscle spasm produces pain, which then produces more spasm. Some people with short-term muscle spasm may experience discomfort for longer than 2 weeks.

Prescription muscle relaxers from Health Solutions Network (MPLLC.net)

Medication Quantity Price Shipping Buy
Carisoprodol 350 mg 30 tablets $75 $18
Carisoprodol 350 mg 60 tablets $81 $18
Carisoprodol 350 mg 90 tablets $87 $18
Cyclobenzaprine 10 mg 30 tablets $74 $18
Cyclobenzaprine 10 mg 60 tablets $83 $18
Cyclobenzaprine 10 mg 90 tablets $99 $18

OriginalDrugs.com has prices of the following muscle relaxers prescription drugs:




Brief comparison of muscle relaxers
 
Soma Watson
Flexeril McNeil
Skelaxin King
 
Carisoprodol
Soma (Watson)
Cyclobenzaprine
Flexeril (McNeil)
Metaxalone
Skelaxin (King)
FDA approval date
April 09, 1959
August 26, 1977
August 13, 1962
Pharmaceutical
Forms
350 mg tablets
5 mg, 10 mg tablets
800 mg tablets
FDA approved indications
  • relief of discomforts associated with acute, painful musculoskeletal conditions
  • relief of muscle spasm associated with acute, painful musculoskeletal conditions
  • relief of discomforts associated with acute, painful musculoskeletal conditions
Most common
side effects
  • drowsiness
  • dizziness
  • ataxia
  • tremor
  • agitation
  • drowsiness
  • dry mouth
  • dizziness
  • drowsiness
  • dizziness
  • headache
Less common
side effects
  • irritability
  • headache
  • depressive reactions
  • insomnia
  • nausea
  • vomiting
  • tachycardia
  • atigue/tiredness
  • asthenia
  • nausea
  • constipation
  • dyspepsia
  • unpleasant taste
  • blurred vision
  • headache
  • nervousness
  • tachycardia
  • arrhythmia
  • nervousness
  • nausea
  • vomiting
  • gastrointestinal upse
Onset/ Duration of action
Onset: 30 min
Duration: 4-6 hours
Onset: 1 hour
Duration: 12-24 hours
Onset: 30 min- 1 hour
Duration: 4- 6 hours
Generic avalability
Yes
Yes
No



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