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Viagra (Sildenafil)

Viagra (Sildenafil Citrate), discovered by Pfizer, is available on the market since 1998 and has earned prominent public recognition. Sildenafil has the longest patient experience and the most extensive data confirming its efficacy for sexual dysfunction (impotence).

Sildenafil increases the body's ability to achieve and maintain an erection during sexual stimulation. It is often prescribed for erection problems due to antidepressants or psychotropics.

Interestingly, sildenafil seems to be a promising sexual enhancer for women. Researchers suggest, that it may enhance vasodilation in the clitoris and relaxation of vaginal smooth muscle, improving sexual function in women.

Onset of action: 30-60 minutes.
Duration: up to 4 hours.
Effectiveness: effective in about 80% of cases of ED regardless of the root cause and man's age.

Viagra should be used with caution by people who have a heart disease or high blood pressure.

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How to use?

  • Viagra is not for regular use. Take it only if you plan to have intimate relations, approximately 60 minutes before sexual activity.
  • Avoid high-fat meals. It works faster on an empty stomach.
  • Sexual stimulation is required for an erection to occur after taking sildenafil. It is not an aphrodisiac and has no effect when you are not sexually aroused.
  • If an erection persists longer than 4 hours, seek immediate medical assistance. If not treated promptly, irreversible damage to the erectile tissue may result.
  • Viagra has a pretty high potential for interactions. Do not use Sildenafil Citrate if you are taking any nitrates (dinitrate, nitroglycerin, isosorbide). Combining Viagra with nitrates can cause a severe drop in blood pressure.
  • Vision disturbances are more common after Viagra, than after other PDE-5 inhibitors. In July 2005, the FDA found that sildenafil could lead to vision impairment in rare cases and a number of studies have linked its use with nonarteritic anterior ischemic optic neuropathy.

Viagra dosage

Doses range from 25 mg to 100 mg, depending on the needed effect. If you buy Viagra for the first time start with the initial dosage of 50 mg. If you are over 65, have liver or kidney problems, or are taking potent CYP3A4 inhibitors a dose of 25 mg may be sufficient.

Viagra may be taken anywhere from 0.5 to 4 hours before sexual activity. Some men need to take sildenafil 3 or 4 times before it works. The maximum recommended dose is 100 mg.

How Viagra works?

Sildenafil is a Phosphodiesterase Enzyme Inhibitor. It works by increasing the blood flow to the penis, essential for successful love-making.

Sildenafil enhances the effects of nitric oxide (NO) by inhibiting phosphodiesterase type 5 (PDE5) in the corpus cavernosum. When sexual stimulation causes local release of NO, inhibition of PDE5 causes increased levels of cyclic guanosine monophosphate (cGMP) in the erectile tissue, resulting in smooth muscle relaxation and inflow of blood.

Sildenafil is sold as Revatio for pulmonary arterial hypertension (PAH).

Quick facts

Pfizer Viagra
  • Viagra was first tried - unsuccessfully - for heart disease, because it increases blood flow to the heart.
  • Although it didn't work as planned, the users were reluctant to stop taking it. Doctors quickly discovered why: it enhances the effects of chemicals that the body normally releases during sexual arousal, thereby allowing an increase of blood flow into the penis.