OriginalDrugs

Trazodone Without a Prescription

  • Generic name: Trazodone hydrochloride
  • Brand names: Desyrel, Trazonil
  • Class: Antidepressant, Phenylpiperazine derivative

Trazodone hcl (Desyrel) is used to relieve symptoms of depression. Besides being an antidepressant, it also has anxiolytic and hypnotic properties. It is good as a short-term treatment for anxiety when mild sedative is needed.

Trazodone is the most common off-label prescription for insomnia and sleep difficulties. Many doctors prescribe it as hypnotic because it is sedating, quite safe, easy to titrate, and inexpensive.

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More Information

Trazodone (Desyrel) is relatively safe and non-habit-forming. It is technically considered to be an antidepressant, but due to its sedative properties is actually used more often for insomnia.

How to take

  • Very serious interactions may occur with sibutramine, MAO inhibitors, other antidepressants, hypnotics, St. John's wort. Therefore, don't start any new prescription without talking to your doctor or pharmacist.
  • Although extremely rare, Trazodone may cause priapism, a persistent, painful erection of the penis. Men who experience prolonged or inappropriate erections should stop taking Trazodone hydrochloride and consult their doctor.
  • Take the medicine shortly after a meal or light snack. You may be more apt to feel dizzy or light-headed if you take it before a meal.
  • It may take 1 to 4 weeks for antidepressant to work. Do not stop taking it without consulting with doctor.
  • Trazodone may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use it with caution. Do not drive or perform other possibly unsafe tasks.

Trazodone as sleep aid

It is used to treat insomnia caused by selective serotonin reuptake inhibitors and is a good choice for depressed people with difficulty sleeping.

Because trazodone hydrochloride (Desyrel) has virtually no potential for abuse and addiction, it may be preferred to benzodiazepines in persons with a history of substance abuse. It does not affect sleep latency but does decrease REM sleep.

The initial prescription dose for trazodone is 25 mg at bedtime. If necessary, it can be slowly up-titrated up to 200 mg.

Dosage

The usual starting dosage is a total of 150 mg per day, divided into 2 or more smaller doses. Your doctor may increase the dose by 50 mg per day every 3 or 4 days, but no more than 400 mg of Trazodone per day. Once you have responded well, the dose may be gradually reduced. Because Trazodone hydrochloride has sedative properties, try to take the largest dose at bedtime.

Read the prescription label before you start the treatment and each time you get an online refill. You need to understand the potential risks, particularly if you buy trazodone or Desyrel without visiting your doctor.

Quick facts

Trazodone hcl
  • Trazodone was originally developed in the 1960s by Italian researchers at Angelini laboratories.
  • It is non-addictive and not habit forming antidepressant.
  • Because Trazodone has strong sedating properties it is often used in a single nighttime dose as sleep aid.
  • Unlike the TCA's, which can be dangerous in overdose, Desyrel was the first antidepressant that was not lethal when overdosed.