|
Buy Trazodone (Desyrel) No Prescription Required
Trazodone (Desyrel) Brief Information
- Active ingredient: trazodone hydrochloride
- Brand names: Desyrel, Sideril, Trazalon; Trazonil
- Drug class: Antidepressant, Phenylpiperazine derivative
- Pregnancy Category: C
- Dosages: 50 mg, 100 mg, 150 mg, 300 mg tablets
- FDA approved: 1982
- Habit forming? No
- Avalable as generic? Yes
- Trazodone
medical info
Trazodone Buying Information
| Medication |
Quantity |
Pharmacy |
Price |
Shipping |
Buy |
| Trazodone 50 mg |
30 tablets |
JRB Health Solutions LLC |
$72 |
$15 |
|
| Trazodone 50 mg |
60 tablets |
JRB Health Solutions LLC |
$77 |
$15 |
|
| Trazodone 50 mg |
90 tablets |
JRB Health Solutions LLC |
$79 |
$15 |
|
| Trazodone 100 mg |
30 tablets |
JRB Health Solutions LLC |
$75 |
$15 |
|
| Trazodone 100 mg |
60 tablets |
JRB Health Solutions LLC |
$79 |
$15 |
|
| Trazodone 100 mg |
90 tablets |
JRB Health Solutions LLC |
$84 |
$15 |
|
| Trazodone 150 mg |
30 tablets |
JRB Health Solutions LLC |
$78 |
$15 |
|
| Trazodone 150 mg |
60 tablets |
JRB Health Solutions LLC |
$85 |
$15 |
|
| Trazodone 150 mg |
90 tablets |
JRB Health Solutions LLC |
$94 |
$15 |
|
- JRB Health Solutions LLC payment methods: Mastercard,
Visa, Money Order.
- Customer service: 1-866-966-1452 (9am - 6pm PST), customerservice@eurexsoftwaresystems.com
- Delivery: FedEx next day (Overnight) air delivery, Saturday
delivery also available.
- US based pharmacy. All orders are shipped from US.
- No prior prescription required.
- Free online doctor consultation.
| Medication |
Quantity |
Pharmacy |
Price |
Shipping |
Buy |
Trazodone 100 mg
(generic Desyrel) |
30 tablets |
Easy.md |
$56.99 |
Free |
|
| 60 tablets |
Easy.md |
$98.99 |
Free |
|
| 90 tablets |
Easy.md |
$69.99 |
Free |
|
| 180 tablets |
Easy.md |
$124.99 |
Free |
|
- Easy.md - Overseas International pharmacy.
- Payment methods: Visa, Mastercard.
- Shipping: Easy.md ship to every country in the world.
Shipping is free regardless of destination. Orders are
shipped by Registered Air Mail.
- Delivery to US: Delivery time to the USA is typically
10 business days.
- No prior prescription required.
Buy Trazodone online without prescription
If you would like to buy Trazodone without prescription online,
choose the offer from the above price tables and click on the Buy
link. You will be taken to the secure server of our suppliers,
US based companies Health Solutions Network (subsidiary of Millenium
Pharmaceuticals, LLC) or JRB Health Solutions LLC, to complete your
Trazodone order.
Quality of the medication you are buying: quality FDA approved Trazodone.
Shipping: US based pharmacy will ship your Trazodone via FedEx Next
Day Air (Overnight) shipping and you are guaranteed
to receive it.
Detailed Information
Trazodone (brand names: Desyrel, Trazon, Trialodine) is a psychoactive
compound with sedative, anxiolytic and antidepressant properties.
Trazodone is used to relieve symptoms of depression such as feelings
of sadness, worthlessness, or guilt; loss of interest in daily activities;
changes in appetite; tiredness; insomnia. It decreases the insomnia
caused by selective serotonin reuptake inhibitors and is a good
choice for depressed patients with difficulty sleeping.
Trazodone is chemically unrelated to the serotonin reuptake inhibitors
(SSRIs), the tricyclic antidepressants (TCAs) or the monoamine oxidase
inhibitors (MAO inhibitors). It is chemically related to nefazodone
and shares its actions. The drug possesses antidepressant, and also
some anxiolytic and hypnotic activity.
Trazodone is a relatively safe, non-habit-forming medication that
is technically considered to be an antidepressant, but is actually
used more often simply to help the individual get a good night?s
sleep. It is also a good short-term alternative treatment for anxiety
or when a mild sedative is needed.
Trazodone is best taken with food, so take it after dinner, or
dessert, to ensure a quality night's rest.
Off-label Uses
- insomnia (3, 5, 6)
- panic/anxiety (2)
- obsessive-compulsive disorder (7)
- depressive phase of bipolar (manic-depressive) disorder.
- attention-deficit/hyperactivity disorder
- opiate withdrawal (11)
- pain syndromes (8, 9)
- essential tremor
- chronic fatigue
- irritable bowel syndrome (IBS)
- bulimia nervosa (4)
- enuresis (bed-wetting)
- aggression
Advantages:
- good choice for insomnia combined with mild depression or anxiety
- not addictive or habit forming
- the most sedating and least anticholinergic of all the currently
marketed antidepressants
- very well tolerated in geriatric patients
- has an advantage over traditional hypnotics in that it does
not depress respiration, an attribute that could be relevant in
persons with sleep apnea
- in
cases of overdose, trazodone alone has not caused a single death
- no restrictions on long-term prescription
- good safety and efficacy for patients with chronic depression
when used up to 5 1/2 years
- low cost
Disadvantages:
- some evidence of tolerance (after 1-2 weeks) especially for
primary insomnia
- risk of priapism and drug-induced penile erections (incidence
1:6000, usually in the first 4 weeks)
- risk of orthostatic hypotension
- risk of drug interactions due to cytochrome metabolism
Trazodone for insomnia:
Trazodone is commonly used in the treatment of insomnia at doses
of 25 mg to 150 mg. This medication may be especially useful in
persons with associated anxiety, depression, or psychosis. Trazodone
can significantly improve insomnia, with little tolerance developing
to its hypnotic effect. Its actions on sleep have been hypothesized
to be mediated through 5-HT2 serotonergic receptor antagonism or
through alpha-adrenergic antagonism. Polysomnographic studies of
patients with various kinds of insomnia have found that trazodone's
main effect on sleep architecture is an increase in slow-wave (stages
3 and 4) sleep. Trazodone improves sleep not only in major depressive
disorder and dysthymic disorder but also in chronic primary insomnia
and in insomnia associated with other antidepressant medications
such as SSRIs and monoamine oxidase inhibitors (MAOIs).
How long does it take to work:
The therapeutic effects of trazodone, like other antidepressants,
appear slowly. It is considered it may take up to 4 weeks for Trazodone
before you begin to feel better.
However, unlike most reuptake inhibitors, Trazodone works for 75%
of people within 2 weeks. If it is going to work at all, that is.
Average time to clear out of your system:
It takes about 3 days for Trazodone to clear out of your system.
Approximately 60 to 70% of C14-labelled trazodone was found to be
excreted in the urine within 2 days and 9 to 29% in feces over 60
to 100 hours.
Dosage
The dose of trazodone will be different for each patient. Treatment
should be started with low initial doses of 75 to 150 mg daily in
divided doses or in an evening single dose. The dose may be increased
slowly to a maximum of 300 mg daily in ambulatory patients and to
600 mg daily in hospitalized patients. Geriatric and emaciated patients
should begin with 100 mg daily, but may be slowly increased to 300
mg. This medication is usually taken with a meal or light snack
two or more times a day.
Trazodone versus Other Antidepressants
Comparison with Imipramine
A 6-week double blind non-crossover study have shown that trazodone
may have an earlier anxiolytic effect than imipramine and a greater
antidepressant effect. With respect to side effects Imipramine has
significantly greater frequency of impaired visual accommodation.
(Comparison
of the efficacy and safety of trazodone and imipramine in endogenous
depression)
Comparison with Amitriptyline
A double-blind study was conducted to determine the efficacy and
safety of trazodone vs. amitriptyline and placebo for neurotic depression.
Trazodone was found to be significantly better than placebo on almost
every rating scale. Trazodone was superior to amitriptyline in some
patients while amitriptyline was only occasionally better than placebo.
Significant improvement was noted in trazodone patients within the
first seven days of therapy. Trazodone produced a low level of side
effects compared to amitriptyline. (A
double-blind study)
Comparison with Bupropion (Wellbutrin)
In a two-center, double-blind clinical trial of outpatients with
moderate to severe major depression the overall efficacy for each
of the two drugs was similar. Improvement in the trazodone treatment
group was significantly greater on day 7 because of the effects
on sleep. At the end of treatment, 58% of the bupropion-treated
patients and 46% of the trazodone-treated patients were considered
much or very much improved. Anorexia and anxiety were reported significantly
more often with bupropion, whereas somnolence, appetite increase,
and edema were reported significantly more often with trazodone.
(Comparison
of bupropion and trazodone)
Comparison with Zolpidem (Ambien)
In placebo controlled trilal subjective sleep latency and duration
showed significant improvement with both trazodone and zolpidem
vs. placebo. However, effect was greater with zolpidem.
Comparison with Fluoxetine (Prozac)
The efficacy and safety of fluoxetine and of trazodone were compared
in a trial in outpatients with major depressive episode. With regard
to efficacy both medications were similarly effective.
More fluoxetine-treated patients reported rhinitis and tremor, while
more trazodone-treated patients reported somnolence and dizziness.
More combined events suggesting activation (agitation, anxiety,
nervousness, insomnia) were reported with fluoxetine than with trazodone,
while more combined events suggesting sedation (somnolence, asthenia)
were reported with trazodone than with fluoxetine. (Fluoxetine
versus trazodone)
Fluoxetine has a slower onset of antidepressant action than does
trazodone. (A
comparative trial of fluoxetine versus trazodone)
Comparison with Gabapentin (Neurontin)
Alcohol-dependent outpatients with persisting insomnia were treated
with either gabapentin or trazodone. Both medications were significantly
effective on the Sleep Problems Questionnaire. But patients treated
with gabapentin improved significantly more than the patients treated
with trazodone (1).
Comparison with Venlafaxine (Effexor)
A double-blind, placebo-controlled trial compared the safety and
efficacy of venlafaxine and trazodone for major depression. Venlafaxine
produced more improvement in the cognitive disturbance and retardation
factors on the Hamilton Rating Scale for Depression. Trazodone was
more effective against the sleep disturbance factor. Patients on
venlafaxine were most likely to enter the long-term phase and to
remain in the trial longest. Venlafaxine was most likely to cause
nausea, whereas trazodone was associated with the most dizziness
and somnolence (10).
Comparison with Mirtazapine (Remeron)
In a double-blind controlled study in hospitalized patients with
major depression mirtazapine showed significant clinical advantages
over trazodone in terms of overall efficacy and tolerability. (Mirtazapine
is more effective than trazodone)
References
- 1. Karam-Hage M, Brower KJ. Open pilot study of gabapentin
versus trazodone to treat insomnia in alcoholic outpatients. Psychiatry
Clin Neurosci. 2003 Oct;57(5):542-4. PubMed
- 2. Mavissakalian M, Perel J, Bowler K, Dealy R. Trazodone in
the treatment of panic disorder and agoraphobia with panic attacks.
Am J Psychiatry. 1987 Jun;144(6):785-7. PubMed
- 3. Nierenberg AA, Adler LA, Peselow E, Zornberg G, Rosenthal
M. Trazodone for antidepressant-associated insomnia. Am J Psychiatry.
1994 Jul;151(7):1069-72. PubMed
- 4. Pope HG Jr, Keck PE Jr, McElroy SL, Hudson JI. A placebo-controlled
study of trazodone in bulimia nervosa. J Clin Psychopharmacol.
1989 Aug;9(4):254-9. PubMed
- 5. Saletu-Zyhlarz GM, Abu-Bakr MH, Anderer P, Gruber G, Mandl
M, Strobl R, Gollner D, Prause W, Saletu B. Insomnia in depression:
differences in objective and subjective sleep and awakening quality
to normal controls and acute effects of trazodone. Prog Neuropsychopharmacol
Biol Psychiatry. 2002 Feb;26(2):249-60. PubMed
- 6. Scharf MB, Sachais BA. Sleep laboratory evaluation of the
effects and efficacy of trazodone in depressed insomniac patients.
J Clin Psychiatry. 1990 Sep;51 Suppl:13-7. PubMed
- 7. Prasad A. Efficacy of trazodone as an anti obsessional agent.
Pharmacol Biochem Behav. 1985 Feb;22(2):347-8. PubMed
- 8. Schreiber S, Backer MM, Herman I, Shamir D, Boniel T, Pick
CG. The antinociceptive effect of trazodone in mice is mediated
through both mu-opioid and serotonergic mechanisms. Behav Brain
Res. 2000 Sep;114(1-2):51-6. PubMed
- 9. Ventafridda V, Caraceni A, Saita L, Bonezzi C,
De Conno F, Guarise G, Ramella G, Silvani V, Tamburini
M, Toscani F. Trazodone for deafferentation pain. Comparison
with amitriptyline. Psychopharmacology (Berl). 1988;95 Suppl:S44-9.
PubMed
- 10. Cunningham LA, Borison RL, Carman JS, Chouinard G,
Crowder JE, Diamond BI, Fischer DE, Hearst E. A comparison
of venlafaxine, trazodone, and placebo in major depression. J
Clin Psychopharmacol. 1994 Apr;14(2):99-106. PubMed
- 11. Pozzi G, Conte G, De Risio S. Combined use of trazodone-naltrexone
versus clonidine-naltrexone in rapid withdrawal from methadone
treatment. A comparative inpatient study. Drug Alcohol Depend.
2000 Jun 1;59(3):287-94. PubMed
Interesting facts
- Trazodone was originally developed in Italy in the 1960s as
a second-generation antidepressant.
- It is non-addictive / not habit forming antidepressant.
- As Trazodone has strong sedating properties it is often used
in a single nighttime dose as a sleep aid.
- Approved by the U.S. FDA in 1982, this drug is chemically related
to Serzone (Nefazodone) and shares its actions.
- Unlike the TCA’s, which can be toxic in overdose however, Trazodone
was the first antidepressant developed that was not lethal when
overdosed.
- Off-Label uses of Trazodone (Desyrel):
Panic/Anxiety
Sleep disorders
Bipolar depression
Chronic fatigue
Fibromyalgia
Irritable Bowel Syndrome
Eating disorders
|