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September 08, 2008

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Buy Levaquin No Prescription


Levaquin Breaf Information
  • Active ingredient: Levofloxacin
  • Common brand names: Levaquin
  • Drug class: Fluoroquinolone antibiotic
  • FDA Approved: December 20, 1996
  • Manufacturer: Ortho-McNeil Pharmaceutical
  • Dosages: 250 mg, 500 mg tablets
  • Pregnancy Category: C
  • Habit forming? No
  • Levaquin instructions

Levaquin Buying Information

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Levaquin 250 mg 10 tablets JRB Health Solutions LLC $162 $15
Levaquin 250 mg 30 tablets JRB Health Solutions LLC $337 $15
Levaquin 500 mg 10 tablets JRB Health Solutions LLC $179 $15
Levaquin 500 mg 30 tablets JRB Health Solutions LLC $391 $15
Levaquin 750 mg 7 tablets JRB Health Solutions LLC $216 $15
Levaquin 750 mg 14 tablets JRB Health Solutions LLC $358 $15

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Levaquin Detailed Information

Levofloxacin (brand name: Levaquin) is a third generation broad spectrum fluoroquinolone antibiotic. This drug is used to treat bacterial infections including sinusitis, chronic bronchitis, pneumonia, skin and skin structure infections, pyelonephritis (mild to moderate), urinary tract infections, inhalational anthrax (to prevent the development of inhalational anthrax following exposure to Bacillus anthracis).

Levofloxacin works by entering the bacterial cell and inhibiting a DNA-gyrase which is involved in the production of genetic material (DNA). This prevents the bacteria from reproducing and their growth is stopped.

Advantages:

  • effective antibiotic for highly resistant pneumococci [2]
  • highly active against atypical respiratory pathogens (Legionella pneumophila, Mycoplasma pneumoniae, Chlamydia pneumoniae ) [3]

Disadvantages:

  • may cause tendonitis and arthropathies

Levaquin versus other Antibiotics

Levaquin versus Cefdinir
The multicenter, double-blind study compared the efficacy and tolerability of cefdinir and levofloxacin in patients with acute rhinosinusitis. Clinical cure rates in the cefdinir and levofloxacin groups were 83% and 86%. The study have shown that cefdinir and levofloxacin have comparable efficacy in the treatment of infections classified as moderate to severe. The incidence of adverse events was generally comparable in the 2 treatment groups. However, cefdinir had greater rate of incidence of vaginal moniliasis in women (11% vs 0%), drug-related diarrhea (8% vs 1%). Levofloxacin had a higher incidence of insomnia (0% for cefdinir vs 4% for levoflxacin) [1].

Levaquin no prescription - new fluoroquinolone.
Although the quinolone class of drugs has been in existence since 1962, only since the fluorination of the molecule in 1983 has the class been considered a major antibacterial group. The classic fluoroquinolones such as ciprofloxacin, norfloxacin, fleroxacin and ofloxacin have had strong activity against Gram-negative bacteria, but the effectiveness of these compounds against Gram-positive bacteria has been debated. The fluoroquinolones developed during the 1990s, notably levofloxacin, gatifloxacin, moxifloxacin and gemifloxacin, have demonstrated enhanced activity against the most common bacteria involved in lower respiratory tract infection (LRTI). Compared with older quinolones such as Norfloxacin (Noroxin) and Ciprofloxacin (Cipro), the newer agents have an expanded antimicrobial spectrum and new indications. The most recently released agents have significant antimicrobial activity against gram-positive streptococci, atypical pathogens and anaerobes.

All new fluoroquinolones (gatifloxacin, levofloxacin, moxifloxacin) have a bactericidal activity and a post-antibiotic effect. Compared with Ciprofloxacin, all new fluoroquinolones have a longer elimination half-life that allows once daily dosing. In addition, these antibiotics have excellent penetration into respiratory tissues, with the highest concentrations found in the epithelial lining fluid and alveolar macrophages.

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References
  • 1. Henry DC, Kapral D, Busman TA, Paris MM. Cefdinir versus levofloxacin in patients with acute rhinosinusitis of presumed bacterial etiology: a multicenter, randomized, double-blind study. Clin Ther. 2004 Dec;26(12):2026-33. PubMed
  • 2. Cunha BA. Clinical relevance of penicillin-resistant Streptococcus pneumoniae. Semin Respir Infect. 2002 Sep;17(3):204-14. PubMed
  • 3. Critchley IA, Jones ME, Heinze PD, Hubbard D, Engler HD, Evangelista AT, Thornsberry C, Karlowsky JA, Sahm DF. In vitro activity of levofloxacin against contemporary clinical isolates of Legionella pneumophila, Mycoplasma pneumoniae and Chlamydia pneumoniae from North America and Europe. Clin Microbiol Infect. 2002 Apr;8(4):214-21. PubMed
Interesting facts

non prescription  levofloxacin

buy levofloxacin without prescription
  • Levofloxacin is an advanced generation fluoroquinolone antibiotic, marketed by Ortho-McNeil under the trade name Levaquin in the US.
  • Chemically, levofloxacin is the S-enantiomer (L-isomer) of ofloxacin, and has approximately twice the potency of ofloxacin.
  • Levofloxacin is currently the only respiratory fluoroquinolone approved by the US FDA for the treatment of nosocomial pneumonia.



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