Imitrex (Sumatriptan) Prescription

• Generic name: Sumatriptan succinate
• Brand names: Imitrex, Imigran
• Therapeutic class: Antimigraine agent, Serotonin 5-HT1B, 1D Receptor Agonist

Imitrex (sumatriptan succinate) is a serotonin receptor agonist, known as "triptan". It is used to treat migraines with or without aura (flashing lights, wavy lines, dark spots) and is effective when used at any time during the attack. Also, it may be prescribed for acute cluster headaches.

Very effective migraine-specific agent...
Imitrex provides rapid relief from migraine with the onset of relief within 30 minutes. It aborts the attack in about 60-70% of migraineurs within 2 h [1]. Sumatriptan relieves both the headache and accompanying symptoms such as nausea and sensitivity to light (photophobia) and sound (acousticophobia). It is suitable as a long-term treatment.

...But not suitable for everyone
A major concern with Sumatriptan is its potential to cause cardiovascular and vasospastic side effects. Triptans are contraindicated for people with known cardiovascular or cerebrovascular diseases. Seniors and people with cardiovascular risk factors, but without established disease, should use Imitrex with caution under the physician's supervision.

Buy Sumatriptan (Generic Imitrex)

Imitrex patent protection has expired in 2009. US Customers can request FDA-approved generic Imitrex and receive the prescription instructions provided by U.S. physician.

Description	Quantity	Pharmacy	Price	Buy
Imitrex 25 mg	9 tablets	MPLLC	$74
Imitrex 25 mg	27 tablets	MPLLC	$125
Imitrex 50 mg	9 tablets	MPLLC	$76
Imitrex 50 mg	27 tablets	MPLLC	$128
Imitrex 100 mg	9 tablets	MPLLC	$78
Imitrex 100 mg	27 tablets	MPLLC	$129

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Description	Quantity	Pharmacy	Price	Buy
Sumatriptan 100 mg	12 tablets	4RX	$50
Sumatriptan 100 mg	24 tablets	4RX	$89
Sumatriptan 100 mg	48 tablets	4RX	$159
Sumatriptan 100 mg	96 tablets	4RX	$299

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How does it work?

Migraine is a neurovascular headache. Sumatriptan works by narrowing blood vessels in the brain.

Sumatriptan succinate is a vascular serotonin receptor agonist. It stimulates 5-HT receptors of the 1D subtype. This specific receptor subtype is present in the cranial and basilar arteries and mediates vasoconstriction. Activation of these receptors causes vasoconstriction of dilated arteries. Sumatriptan also blocks the release of vasoactive neuropeptides during migraine and may inhibit the release of inflammatory mediators from the trigeminal nerve.

Imitrex is an excellent migraine-abortive agent, but not a preventive.

Dosage

It is advisable to take Imitrex as soon as you notice symptoms of a migraine attack.

The initial dose for adults is 25, 50, or 100 mg taken with water or other liquid. The most you should take at one time is 100 mg, and the most you should take in 1 day is 200 mg. If you have liver disease, you should not take more than 50 mg at one time.

If your migraine goes away and then comes back, or if you have a partial response to the first dose, you may take a second after at least 2 hours. If the first dose has not helped you even slightly, then Imitrex probably will not work at all.

In the United Kingdom, sumatriptan (Imigran Recovery) has been available without a prescription since 2006.

• 1. Ferrari MD, James MH, Bates D, Pilgrim A, Ashford E, Anderson BA, Nappi G. Cephalalgia. 1994 Oct;14(5):330-8.