Brand Name: Dynacin, Minocin, Vectrin
Generic Name: Minocycline
The following product information is not a substitute for physician's
or manufacturer's instructions.
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Minocycline Medical Uses:
Minocycline is a tetracycline antibiotic. Minocycline is used to treat
skin infections, urinary tract infections, gallbladder infections, protozoal
infections, respiratory tract infections such as bronchitis, pneumonia,
and sinusitis.
Minocycline Dosage, How to Take:
- Dosage for bacterial or protozoal infections (adults and teenagers):
200 mg at first, then 100 mg every twelve hours; or 100 to 200 mg
at first, then 50 mg every six hours.
- Dosage for children older than 8 years of age: Dose is based on
body weight. The usual dose is 4 mg per kilogram (kg) (1.8 mg per
pound) of body weight at first, then 2 mg per kg (0.9 mg per pound)
of body weight every twelve hours.
- Infants and children 8 years of age and younger: Tetracyclines are
usually not used in young children because tetracyclines can permanently
stain teeth.
Possible Side Effects:
Like all medicines, Minocycline may cause unwanted effects (side effects)
in some people.
Tell your doctor if any of these symptoms continue or are bothersome:
- diarrhea
- nausea
- abdominal pain
- vomiting
- dizziness,
- increased sensitivity of the skin to sunlight
- sore mouth
- vaginal yeast infection
The following side effects are rare, but you should contact your doctor
immediately if any of them happen to you:
- allergic reaction (difficulty breathing or swallowing; closing of
the throat; swelling of the lips, tongue, or face; hives)
- skin rash or itching
- unusual bleeding or bruising
- liver damage (yellowing of the skin or eyes, dark urine, abdominal
pain)
- irritation of the esophagus
- severe headache
- extreme tiredness or weakness
The following syndromes have been reported. As with other serious adverse
reactions, if any of these syndromes are recognized, the drug should
be discontinued immediately:
- Hypersensitivity syndrome consisting of cutaneous reaction (such
as rash or exfoliative dermatitis), eosinophilia, and one or more
of the following: hepatitis, pneumonitis, nephritis, myocarditis,
and pericarditis. Fever and lymphadenopathy may be present.
- Lupus-like syndrome consisting of positive antinuclear antibody;
arthralgia, arthritis, joint stiffness, or joint swelling; and one
or more of the following: fever, myalgia, hepatitis, rash, and vasculitis.
- Serum sickness-like syndrome consisting of fever; urticaria or rash;
and arthralgia, arthritis, joint stiffness, or joint swelling. Eosinophilia
may be present.
Minocycline Precautions:
Before taking Minocycline, tell your doctor or pharmacist if you have
any of these conditions:
- allergic reaction to Minocycline, or other tetracyclines
- kidney disease
- liver disease
- diabetes
- lupus
This medicine can cause the skin to react abnormally to direct sunlight
and UV light, causing an exagerated sunburn reaction. Avoid exposing your
skin to direct sunlight and UV light while taking this medicine. This
sunlight sensitivity can continue for two weeks to several months after
stopping Minocycline.
Minocycline is not generally approved for treating patients under 8 years
old.
Do not take any Minocycline after the expiration date printed on the
bottle. Expired Minocycline can cause a dangerous syndrome resulting in
damage to the kidneys.
Pregnancy & Breast Feeding:
Pregnancy Category D. Minocycline, like other tetracycline-class
antibiotics, crosses the placenta and may cause fetal harm when administered
to a pregnant woman. Rare spontaneous reports of congenital anomalies
including limb reduction have been reported in post-marketing experience.
Only limited information is available regarding these reports; therefore,
no conclusion on causal association can be established. If Minocycline
is used during pregnancy or if the patient becomes pregnant while taking
this drug, the patient should be apprised of the potential hazard to
the fetus.
Tetracyclines are excreted in human milk. Because of the potential
for serious adverse reactions in nursing infants from the tetracyclines,
a decision should be made whether to discontinue nursing or discontinue
the drug, taking into account the importance of the drug to the mother.
Drug Interactions:
Minocycline may interact with the following drugs:
- Antacids
- Anticoagulants
- Antivirals
- Bismuth subsalicylate
- Calcium supplements
- Carbamazepine
- Cefixime
- Cholestyramine or colestipol
- Oral Contraceptives
- Desmopressin
- Digitalis preparations
- Etretinate
- Lithium
- Mineral supplements (iron, calcium, magnesiun, zinc)
- Panicillins
- Sodium bicarbonate
- Vitamin A
Overdose:
The adverse events more commonly seen in overdose are dizziness, nausea,
and vomiting. In case of overdosage, discontinue medication, treat symptomatically
and institute supportive measures.
Related information:
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