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Lasix side effects, dosage, uses
Brand Name: Lasix
Generic Name: Furosemide
The following product information is not a substitute for physician's
or manufacturer's instructions.
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Lasix Medical Uses:
Lasix (furosemide) is a loop diuretic. It is used to treat excessive
fluid accumulation and swelling (edema) of the body caused by heart
failure, cirrhosis, chronic kidney failure, and nephrotic syndrome.
It is sometimes used in conjunction with other blood pressure pills
to treat high blood pressure. It also may be used for the reatment of
hyperkalemia.
Lasix Dosage:
- Edema: 20 to 600 mg daily; depending on the severity.
- Hypertension: 40 to 80 mg daily.
- Chronic renal insufficiency: 250 mg (increased every 4 hours to
a total dose of up to 2 g in 24 hours).
Possible Side Effects:
Lasix (furosemide) can cause the following adverse reactions:
- Gastrointestinal: pancreatitis, jaundice, anorexia, oral and gastric
irritation, cramping, diarrhea, constipation, nausea, vomiting
- Hypersensitivity reactions: systemic vasculitis, interstitial nephritis,
necrotizing angiitis
- CSN reactions: tinnitus and hearing loss, paresthesias, vertigo,
dizziness, headache, blurred vision, xanthopsia
- Hematologic reactions: aplastic anemia (rare), thrombocytopenia,
agranulocytosis (rare), hemolytic anemia, leukopenia, anemia
- Dermatologic-hypersensitivity reactions: exfoliative dermatitis,
erythema multiforme, purpura, photosensitivity, urticaria, rash, pruritus
- Cardiovascular reaction: orthostatic hypotension may occur and be
aggravated by alcohol, barbiturates or narcotics.
- Other adverse reactions: hyperglycemia, glycosuria, hyperuricemia,
muscle spasm, weakness, restlessness, urinary bladder spasm,
thrombophlebitis, transient injection site pain following intramuscular
injection, fever
Lasix Precautions:
- Contraindicated in patients with anuria; or in patients with renal
failure; when caused by nephrotoxic or hepatotoxic drugs.
- Should not be used in patients in renal failure associated with
coma.
- Cases of tinnitus and reversible or irreversible hearing impairment
have been reported.
Pregnancy & Breast Feeding:
Pregnancy Category C . Furosemide has been shown to cause unexplained
maternal deaths and abortions in rabbits at 2, 4 and 8 times the maximal
recommended human oral dose. There are no adequate and well-controlled
studies in pregnant women. Furosemide should be used during pregnancy
only if the potential benefit justifies the potential risk to the fetus.
Because it appears in breast milk, caution should be exercised when
Furosemide is administered to a nursing mother.
Drug Interactions:
Lasix may interact with the following drugs:
- aminoglycoside antibiotics - frusemide can enhance the ototoxic
effects of this class of antibiotics
- ethacrynic acid - possibility of ototoxicity
- lithium - diuretics reduce lithium's renal clearance and add a high
risk of lithium toxicity
- NSAIDs (nonsteroidal anti-inflammatory drugs) -can decrease the
diuretic effects of furosemide
- phenytoin - can decrease the absorption and effectiveness of furosemide
- cephalosporin antibiotics - frusemide may enhance the nephrotoxic
effects of this class of antibiotic
- antihypertensive drugs - frusemide enhances the hypotensive effects
of antihypertensives; particularly in combination with ACE inhibitors
such as captopril
- digoxin - frusemide may deplete potassium to a low level where
the sensitivity of the myocardium is increased and digoxin toxicity
may occur
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