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September 08, 2008


Ibuprofen Side Effects, Dosage, Uses


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Brand Name:
Motrin

Generic Name: Ibuprofen

The following product information is not intended to replace the physician's or manufacturer's instructions.

Ibuprofen Medical Uses:
Ibuprofen is in a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen works by reducing hormones that cause inflammation and pain in the body. Ibuprofen is used to reduce the fever, pain, inflammation, and stiffness caused by many conditions, such as osteoarthritis, rheumatoid arthritis, and abdominal cramps associated with menstruation. Ibuprofen may also be used for purposes other than those listed here.

How to Take Ibuprofen. Ibuprofen Dosage.
Take Ibuprofen exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you. Take each dose with a full glass of water. Take Ibuprofen with food, milk, or an antacid to lessen stomach upset.

Ibuprofen Side Effects:
Ibuprofen appears to have the lowest incidence of gastrointestinal adverse drug reactions (ADRs) of all the non-selective NSAIDs. However, this only holds true at lower doses of ibuprofen.

Common adverse effects include:

  • abnormal renal function
  • anemia
  • dizziness
  • edema
  • elevated liver enzymes
  • fluid retention
  • gastrointestinal (abdominal pain, bloating, constipation, diarrhea, dyspepsia, epigastric pain, flatulence, heartburn, nausea, vomiting)
  • headaches
  • increased bleeding time
  • nervousness
  • pruritus
  • rashes (including maculopapular)
  • tinnitus

Infrequent adverse effects include:

  • oesophageal ulceration
  • heart failure
  • hyperkalaemia
  • renal impairment
  • confusion
  • bronchospasm
  • rash

Congestive Heart Failure and Edema
Fluid retention and edema have been observed in some patients taking NSAIDs. Ibuprofen should be used with caution in patients with fluid retention or heart failure.

Renal Effects
Long-term administration of NSAIDs has resulted in renal papillary necrosis and other renal injury. Renal toxicity has also been seen in patients in whom renal prostaglandins have a compensatory role in the maintenance of renal perfusion. In these patients, administration of a nonsteroidal anti-inflammatory drug may cause a dose-dependent reduction in prostaglandin formation and, secondarily, in renal blood flow, which may precipitate overt renal decompensation. Patients at greatest risk of this reaction are those with impaired renal function, heart failure, liver dysfunction, those taking diuretics and ACE inhibitors, and the elderly.

Ibuprofen Precautions:
Before taking this medication, tell your doctor if you have an allergy to aspirin or any other NSAIDs, have an ulcer or bleeding in the stomach, drink more than three alcoholic beverages a day, have liver or kidney disease, have a coagulation (bleeding or blood clotting) disorder, have congestive heart failure, have fluid retention, have heart disease, or have high blood pressure. You may not be able to take Ibuprofen, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. It is not known whether Ibuprofen will harm an unborn baby. Ibuprofen should not be taken late in pregnancy (the third trimester) because a similar drug is known to affect the baby's heart. Do not take Ibuprofen without first talking to your doctor if you are pregnant. Ibuprofen passes into breast milk in very small amounts, however it is not expected to harm a nursing baby. Talk to your doctor before taking Ibuprofen if you are breast-feeding.

Drug Interactions:
Other prescription and over-the-counter drugs may increase the effects of Ibuprofen and cause dangerous side effects. Tell your doctor if you are taking any of the following drugs: another nonsteroidal anti-inflammatory drug (NSAID) such as ketoprofen (Orudis, Orudis KT, Oruvail), naproxen (Naprosyn, Aleve, Anaprox), diclofenac (Voltaren, Cataflam), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), indomethacin (Indocin), ketorolac (Toradol), nabumetone (Relafen), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), or tolmetin (Tolectin); aspirin or another salicylate (form of aspirin) such as salsalate (Disalcid), choline salicylate, and magnesium salicylate; a diuretic (water pill) such as hydrochlorothiazide (HCTZ, HydroDiuril, others), chlorothiazide (Diuril, others), chlorthalidone (Thalitone), bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), spironolactone (Aldactone), and amiloride (Midamor); an anticoagulant such as warfarin (Coumadin); a steroid such as prednisone (Deltasone); an oral diabetes medication such as glipizide (Glucotrol) or glyburide (Micronase, Diabeta); or lithium (Eskalith, Lithobid, others). Talk to your doctor before taking Ibuprofen if you are taking any other medicines, especially any of the ones listed above. Drugs other than those listed here may also interact with Ibuprofen. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.

Related information:
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