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Fluconazole (Diflucan) Without Prescription

  • Generic name: Fluconazole
  • Brand name: Diflucan, CanesOral (Canada)
  • Class: Antifungal, Triazoles

Diflucan (fluconazole) is broad spectrum antifungal agent. It is used to treat different types of fungal and yeast infections, particularly those caused by Candida or Cryptococcus species of fungi: vaginal thrush (candidiasis), thrush affecting the mouth or throat, systemic candidiasis (urinary tract or other organs), cryptococcal meningitis.

Fluconazole is also effective against fungal skin infections caused by dermatophytes, including tinea corporis (ringworm), tinea cruris (jock itch), and tinea pedis (Athlete's foot).

Fluconazole (generic Diflucan)

Description Quantity Pharmacy Price Buy
Fluconazole 100 mg 30 tablets MPLLC $71
Fluconazole 150 mg 1 tablet MPLLC $58
Fluconazole 150 mg 12 tablets MPLLC $104
Fluconazole 200 mg 30 tablets MPLLC $79
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Diflucan over-the-counter

The single-dose Diflucan from Pfizer was a potential candidate to be sold without a prescription. However, a high rate of side effects such as headache and nausea, reduces the likelihood that people will be able to buy Diflucan over-the-counter.

Since 2010, fluconazole 150 mg is available over-the-counter under the name CanesOral in Canada.

How does Fluconazole work?

Fluconazole is generally fungistatic against yeasts. It works by preventing fungi from producing a substance called ergosterol, which is a component of fungal cell membranes. Without ergosterol as part of the cell membrane, the membrane is weakened and damaged, and essential constituents of the fungal cells can leak out. This kills the fungi.

The usefulness of fluconazole is restricted by its ineffectiveness against Aspergillus sp and limited activity against Candida krusei and Candida glabrata.

It has nearly complete oral bioavailability (>90%).

Fluconazole dosage

To clear up your candidiasis completely, take the full course of Fluconazole. Keep taking it even if you feel better in a few days.

Vaginal yeast (thrush):
A single oral dose of 150 mg is usually effective. It can be repeated. Women with severe vulvovaginal candidiasis may benefit from two 150 mg doses given 3 days apart.

Throat and mouth candidiasis:
200 mg on the first day, followed by 100 mg once a day. You may see results in a few days, but should continue treatment for at least 2 weeks to avoid a relapse.

Candidiasis of the esophagus (gullet):
200 mg on the first day, followed by 100 mg once a day. Up to 400 mg a day can be taken in case of severe infection. Treatment should continue for a minimum of 3 weeks and for at least 2 weeks after symptoms resolve.

Cryptococcal meningitis:
400 mg on the first day, followed by 200 mg once a day. Treatment should continue for 10 to 12 weeks once tests of spinal fluid come back negative.

Fluconazole is not normally used in children but doses of 5 mg/kg/day have been safely prescribed for serious fungal infections.

Important note: Diflucan has been linked to rare cases of serious liver damage, including deaths, mostly in persons with serious health problems.

Quick facts

Fluconazole
  • Fluconazole is the first member of a new subclass of synthetic triazole antifungal agents.
  • It is the only oral, single dose vaginal thrush treatment available.
  • With Fluconazole you should notice an improvement in your symptoms in one day.