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July 24, 2008


Buy Carisoprodol No Prescription


Brief Information
  • Active ingredient: carisoprodol
  • Common brand names: Soma, Carisoma, Somadril
  • Dosages: 350 mg tablets
  • Drug class: Skeletal muscle relaxant, centrally acting
  • FDA approval: April 09, 1959
  • Habit forming? Possibly
  • Avalable as generic? Yes

Buying Information

Medication Quantity Pharmacy Price Shipping Buy
Manufacturer: Mutual Pharmaceutical        
Carisoprodol 350 mg 30 tablets MPLLC.net $75 $18
Carisoprodol 350 mg 60 tablets MPLLC.net $81 $18
Carisoprodol 350 mg 90 tablets MPLLC.net $83 $18
Manufacturer: Qualitest Pharmaceuticals        
Carisoprodol 350 mg 30 tablets MPLLC.net $75 $18
Carisoprodol 350 mg 60 tablets MPLLC.net $81 $18
Carisoprodol 350 mg 90 tablets MPLLC.net $87 $18


  • Health Solutions Network (MPLLC) payment methods: Visa, Money Order, E-check.
  • Delivery: FedEx next day (Overnight) air delivery, Saturday delivery also available.
  • All orders are shipped from US.
  • No prior prescription required.
  • Free online doctor consultation.

Buy Carisoprodol no prescription
If you would like to buy Carisoprodol without prescription online, choose the offer from the above price tables and click on the Buy link. You will be taken to the secure server of our suppliers, US based companies Health Solutions Network (subsidiary of Millenium Pharmaceuticals, LLC) or JRB Health Solutions LLC, to complete your Carisoprodol order.
Quality of the medication you are buying: quality FDA approved Carisoprodol.
Shipping: US based pharmacy will ship your Carisoprodol via FedEx Next Day Air (Overnight) shipping and you are guaranteed to receive it.


Detailed Information

Carisoprodol is a a centrally-acting skeletal muscle relaxant. This drug is an isopropyl derivative of meprobamate. This medicine is used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Carisoprodol works by blocking nerve impulses that are sent to your brain. With an average dose of 350 mg, four times per day, drowsiness and drowsiness are the main side effects.

Off-label uses:

  • Low back pain (2, 3)
  • Fibromyalgia (1)

History
On June 1st 1959 several American pharmacologist convened at Wayne State University, Detroit, MI to discuss a new drug. The drug, originally thought to have antiseptic properties, was found to have central muscle relaxing properties. It had been developed by Dr. Frank M. Berger at Wallace laboratories and had been named carisoprodol.

The misuse and abuse of meprobamate and other muscle relaxing drugs was an item of great concern in the 1950s and 1960s 3-5 . Carisoprodol i was developed in the 1950s on the basis of meprobamate, hoping that it would have better muscle-relaxing properties, less abuse-potential, and less risk of overdose than meprobamate 18 . The substitution of one hydrogen atom with an isopropyl group on one of the carbamyl nitrogens was intended to yield a molecule with new pharmacological properties.

Onset of action: 30 min.

Duration of action: 4 to 6 hr.

Carisoprodol for fibromyalgia
The results of double blind trial indicated that combination of carisoprodol, paracetamol and caffeine are effective in the treatment of fibromyalgia.
Treatment with carisoprodol, paracetamol and caffeine gave statistically significant improvement after treatment for pain, for sleep quality and for the general feeling of sickness. In the active treatment group increased pressure pain threshold after eight weeks was found at 70% of the sites measured, while the pressure pain threshold was increased at only 30% of the sites in the placebo group. In the placebo group improvement was found for the pain and sleep quality. This improvement may in part be due to the large amounts of extra medication in placebo group (1).

Carisoprodol versus Butabarbital
This results of a double-blind study have shown that carisoprodol is significantly more effective than butabarbital or placebo in producing improvement of all factors rated in treatment of the low back syndrome. The effects of carisoprodol are not due solely to sedative action, but are also related to its muscle relaxant activity (3).

The study was carried out to determine the effectiveness of carisoprodol in the treatment of the low back syndrome, and to test whether this drug would produce any greater effect than an active sedative control (butabarbital). 48 Mexican migrant farm laborers with acute lumbar strain and spasm were given either carisoprodol 350 mg, butabarbital 15 mg, or placebo, four times daily for four days, and then were rated on pertinent symptoms, the degree of limitation of motion, and overall improvement. In the 43 patients who could be statistically analyzed, carisoprodol was shown to be significantly more effective than butabarbital or placebo in producing improvement.

Carisoprodol versus Cyclobenzaprine
Cyclobenzaprine and carisoprodol were compared in the treatment of patients with acute thoracolumbar pain and spasm rated moderate to severe and of no longer than seven days duration (4). Both drugs were found to be effective, without significant differences between the treatment groups. Significant improvements were noted in physician rated mobility and in patients' visual analogue scores on follow up days four and eight. While 60% of patients experienced adverse effects in the form of drowsiness or fatigue, these differences were not significantly different between groups, and only eight percent of patients from each group discontinued treatment.

Dosage
Carisoprodol is most often taken therapeutically in doses of 350 mg p.o. up to 3 or 4 times per day. In clinical practice the drug is, however, also ingested in doses of 700 mg up to 3 or 4 times per day.


References
  • 1. Vaeroy H, Abrahamsen A, Forre O, Kass E. Treatment of fibromyalgia (fibrositis syndrome): a parallel double blind trial with carisoprodol, paracetamol and caffeine (Somadril comp) versus placebo. Clin Rheumatol. 1989 Jun;8(2):245-50. PubMed
  • 2. Toth PP, Urtis J. Commonly used muscle relaxant therapies for acute low back pain: a review of carisoprodol, cyclobenzaprine hydrochloride, and metaxalone. Clin Ther. 2004 Sep;26(9):1355-67. PumMed
  • 3. Hindle TH 3rd. Comparison of carisoprodol, butabarbital, and placebo in treatment of the low back syndrome. Calif Med. 1972 Aug;117(2):7-11. PubMed
  • 4. Rollings HE, Glassman JM, Soyka JP. Management of acute musculoskeletal conditions - Thoracolumbar strain or sprain: A double-blind evaluation comparing the efficacy and safety of carisoprodol with cyclobenzaprine hydrochloride. Curr Ther Res. 1983;34(6):917-928.
Interesting facts

facts


  • Carisoprodol is chemically, structurally, and pharmacologically related to meprobamate. Meprobamate is a CNS depressant, indicated for the management of anxiety disorders or for short-term treatment of anxiety symptoms.
  • It is not only a pro-drug to meprobamate, but has effects of its own.
  • In addition to the desired skeletal muscle relaxing effect, carisoprodol produces weak anticholinergic, antipyretic and analgesic properties.
  • This medication is not a federally Schedule IV controlled substance.
  • This agent is Schedule IV controlled substance in the following states:
    Georgia
    Hawaii
    Kentucky
    Massachusetts
    New Mexico
    Oklahoma



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