OriginalDrugs

Bupropion (Wellbutrin SR)

  • Generic name: Bupropion hydrochloride
  • Brand name: Wellbutrin SR, Zyban
  • Drug class: Antidepressant, Dual Norepinephrine and Dopamine Reuptake Inhibitor

Bupropion hydrochloride (Wellbutrin) is a prescription selective norepinephrine and dopamine reuptake inhibitor. This medication is used to treat depression.

Some doctors prescribe Bupropion "off-label" for weight loss, bipolar depression ADD/ADHD, SSRI-induced sexual dysfunction, chronic fatigue syndrom, headaches and irritable bowel syndrome (IBS).

Brand Wellbutrin SR (GlaxoSmithKline)

Dosage Quantity Pharmacy Price Shipping Buy
Wellbutrin SR 150 mg 30 tablets JRB Health Solutions LLC $138 $15
Wellbutrin SR 150 mg 90 tablets JRB Health Solutions LLC $265 $15
Wellbutrin SR 200 mg 30 tablets JRB Health Solutions LLC $189 $15
Wellbutrin SR 200 mg 90 tablets JRB Health Solutions LLC $410 $15

US Pharmacy JRB Health Solutions LLC
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Drug Information

Bupropion regulates certain brain chemicals - dopamine and norepinephrine - to elevate mood. It is believed that depression is caused by chemical imbalances in the brain. Controlling these chemical imbalances will help improve depressive symptoms. This drug is also used to help people quit smoking.

How to take

  • Follow the instructions on your prescription label. Wellbutrin SR, the sustained-release form, is usually taken in 2 doses, at least 8 hours apart.
  • Your doctor will probably start you at a low dosage and gradually increase it; this helps minimize side effects.
  • Do not drink alcohol while you are taking Wellbutrin; an interaction between alcohol and Wellbutrin could increase the possibility of a seizure.
  • Do not stop taking Bupropion without talking to your doctor. You may have withdrawal side effects if you stop antidepressant suddenly.

Bupropion (Wellbutrin SR) prescription dosage

The usual starting dose is 150 mg in the morning. After 3 days, if you do well, your doctor will have you take another 150 mg at least 8 hours after the first dose. It may be 4 weeks before you feel the benefit and you will take the drug for several months. The maximum recommended dose is 400 mg a day, taken in doses of 200 mg each.

If you have severe cirrhosis of the liver, your dosage should be no more than 75 mg once a day. With less serious liver and kidney problems, the dosage will be reduced as needed.

New antidepressant formulation Wellbutrin XL is also available without a prescription.

Quick facts

wellbutrin sr


  • Bupropion may be especially useful in persons greatly concerned about weight gain. It is a chemical derivative of diethylpropion, an amphetamine-like agent used as a weight loss medication.
  • Unlike SSRIs, Bupropion does not affect sexual function in either men or women.
  • The main disadvantages of Bupropion are risk of seizures and potential for drug interactions.