Allopurinol (Zyloprim)

• Generic name: Allopurinol
• Brand name: Zyloprim, Aloprim, Progout, Zyloric
• Class: Antigout, Xanthine Oxidase Inhibitors

Allopurinol is prescribed for the treatment of chronic gout and is used to prevent rather than treat gout attacks. It works by blocking uric acid production. Uric acid is a waste chemical normally present in the blood as a result of the breakdown of purines. Excessive amounts of uric acid (called hyperuricemia) can cause crystals to form in the joints, which can lead to gout.

Allopurinol (Generic Zyloprim)

Quantity	Price	Shipping	Buy
Allopurinol 100 mg 60 tablets	$69	$18
Allopurinol 100 mg 90 tablets	$76	$18
Allopurinol 300 mg 60 tablets	$77	$18
Allopurinol 300 mg 90 tablets	$84	$18

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Indications

Allopurinol (Zyloprim) is used to prevent recurrent gout attacks (two or more per year).

The majority of people with gout are uric acid undersecretors rather than overproducers. Allopurinol hampers the conversion of hypoxanthine to xanthine and the conversion of xanthine to uric acid, thus decreasing the concentration of uric acid. Decreasing the uric acid load will help to limit the frequency and intensity of gout attacks.

Allopurinol appears to resorb tophus, so it may have utility for those with tophaceous gout. It is used in persons intolerant to uricosurics; those with gross overproduction of uric acid, uric acid stones or nephropathy.

Allopurinol is also used to prevent recurrent calcium oxalate calculi.

How to take

You should drink plenty of fluids (at least 8 glasses of water per day) while taking allopurinol. Drinking water can prevent formation of kidney stones.

Don't initiate the xanthine oxidase inhibitor during an acute gout attack.

Gout:
Initiate at 100 mg per day and increase by 100 mg weekly until an adequate response is achieved or a maximum amount of 800 mg per day is reached. The average maintenance amount is 300 mg daily.

It may take several months before the freedom from acute gouty attacks is attained.

Calcium oxalate stones:
200 - 300 mg daily.

Allopurinol amounts over 300 mg should be divided.